Gene
ripk2
- ID
- ZDB-GENE-030902-3
- Name
- receptor-interacting serine-threonine kinase 2
- Symbol
- ripk2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable CARD domain binding activity and JUN kinase kinase kinase activity. Acts upstream of or within antibacterial innate immune response; defense response to virus; and regulation of DNA-templated transcription. Predicted to be active in cytoplasm. Is expressed in brain; gill; liver; pleuroperitoneal region; and unfertilized egg. Orthologous to human RIPK2 (receptor interacting serine/threonine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb45 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| ihb46 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ihb47 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa39769 | Allele with one point mutation | Unknown | Missense, Premature Stop | ENU | |
| z39 | Allele with one deletion | Exon 10 | Frameshift, Premature Stop | CRISPR | |
| z40 | Allele with one insertion | Exon 10 | Frameshift, Premature Stop | CRISPR | |
| z41 | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ripk2 | (5) | |
| CRISPR2-ripk2 | Jurynec et al., 2018 | |
| CRISPR3-ripk2 | Jurynec et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CARD domain | Death-like domain superfamily | Protein kinase domain | Protein kinase-like domain superfamily | Receptor-interacting serine/threonine-protein kinase 2 | RIP2, CARD domain | Serine/Threonine Kinases and Pseudokinases | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q4V958 | InterPro | 584 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-39H5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113971 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:BC097049 (1) | 2441 nt | ||
| Genomic | GenBank:CU694455 (1) | 33562 nt | ||
| Polypeptide | UniProtKB:Q4V958 (1) | 584 aa |
- Fang, H., Wu, X.M., Hu, Y.W., Song, Y.J., Zhang, J., Chang, M.X. (2020) NLRC3-like 1 inhibits NOD1-RIPK2 pathway via targeting RIPK2. Developmental and comparative immunology. 112:103769
- Mai, Y., Peng, S., Li, H., Gao, Y., Lai, Z. (2020) NOD-like receptor signaling pathway activation: A potential mechanism underlying negative effects of benzo(α)pyrene on zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 240:108935
- Cao, L., Wu, X.M., Nie, P., Chang, M.X. (2019) The negative regulation of piscine CD44c in viral and bacterial infection. Developmental and comparative immunology. 96:135-143
- Wu, X.M., Cao, L., Nie, P., Chang, M.X. (2019) Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes. Developmental and comparative immunology. 101:103455
- Jurynec, M.J., Sawitzke, A.D., Beals, T.C., Redd, M.J., Stevens, J., Otterud, B., Leppert, M.H., Grunwald, D.J. (2018) A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis. Human molecular genetics. 27(13):2383-2391
- Wu, X.M., Chen, W.Q., Hu, Y.W., Cao, L., Nie, P., Chang, M.X. (2018) RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Frontiers in immunology. 9:726
- Zou, P.F., Chang, M.X., Li, Y., Xue, N.N., Li, J.H., Chen, S.N., Nie, P. (2016) NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-κB, and also MDA5, RIG-I and MAVS. Fish & shellfish immunology. 55:173-85
- Maharana, J., Dehury, B., Sahoo, J.R., Jena, I., Bej, A., Panda, D., Sahoo, B.R., Patra, M.C., Pradhan, S.K. (2015) Structural and functional insights into CARDs of zebrafish (Danio rerio) NOD1 and NOD2, and their interaction with adaptor protein RIP2. Molecular Biosystems. 11(8):2324-36
- Maharana, J., Patra, M.C., De, B.C., Sahoo, B.R., Behera, B.K., De, S., Pradhan, S.K. (2014) Structural insights into the MDP binding and CARD-CARD interaction in zebrafish (Danio rerio) NOD2: a molecular dynamics approach. Journal of molecular recognition : JMR. 27:260-75
- Oehlers, S.H., Flores, M.V., Hall, C.J., Swift, S., Crosier, K.E., and Crosier, P.S. (2011) The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish. Disease models & mechanisms. 4(6):832-41
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